Rational Drug Design
Dr. Hiroshi Tanaka
LeMay Publishing
MEDICAL
Rational Drug Design
Pharmacology12,480 words26 chapters
Published by LeMay Publishing. 12,480 words across 26 chapters.
About This Publication
Structure-based drug design and translational pharmacology, tracing the evolution from empirical observation and fortuitous discovery to rational, structure-guided therapeutic development.
Published by LeMay Publishing, a division of LeMay. Massachusetts.
ISBN: 979-8-0000-7031-4
Chapters
1RATIONAL DRUG DESIGN
2Structure-Based Drug Design and Translational Pharmacology
3PREFACE
4TABLE OF CONTENTS
5CHAPTER 1
6Historical Foundations and Philosophical Framework of Rational Drug Design
7CHAPTER 2
8Molecular Targets — Identification, Validation, and Structural Characterization
9CHAPTER 3
10Principles of Molecular Recognition and Ligand–Receptor Interactions
11CHAPTER 4
12Computational Approaches to Structure-Based Drug Design
13CHAPTER 5
14Lead Discovery — From Fragment Screening to Hit Identification
15CHAPTER 6
16Lead Optimization — Medicinal Chemistry Strategies and Structure–Activity Relationships
17CHAPTER 7
18Pharmacokinetics and Drug Metabolism in Rational Design
19CHAPTER 8
20Translational Pharmacology — From Bench to Bedside
21CHAPTER 9
22Case Studies in Rational Drug Design
23CHAPTER 10
24Emerging Frontiers and Future Directions
25BIBLIOGRAPHY
26INDEX